Pharmacogenomics and personalized medicine: the plunge into next-generation sequencing
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چکیده
منابع مشابه
Next-Generation Sequencing: From Understanding Biology to Personalized Medicine
Within just a few years, the new methods for high-throughput next-generation sequencing have generated completely novel insights into the heritability and pathophysiology of human disease. In this review, we wish to highlight the benefits of the current state-of-the-art sequencing technologies for genetic and epigenetic research. We illustrate how these technologies help to constantly improve o...
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Pharmacogenetics is a newer branch of pharmacological sciences studying the relationship between genetic predisposition of an individual and his ability to metabolize a drug. It helps understand why some individuals respond to drugs and others do not, why some individuals require higher or lower doses to achieve an optimal therapeutic response, and tries to help the physician identify those pat...
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personalized medicine aims is to supply the proper drug to the proper patient within the right dose. pharmacogenomics (pgx) is to recognize genetic variants that may influence drug efficacy and toxicity. all things considered, the fields cover a wide area, including basic drug discovery researches, the genetic origin of pharmacokinetics and pharmacodynamics, novel drug improvement, patient gene...
متن کامل5. Pharmacogenomics and Personalized Medicine
Pharmacogenetics is a newer branch of pharmacological sciences studying the relationship between genetic predisposition of an individual and his ability to metabolize a drug. It helps understand why some individuals respond to drugs and others do not, why some individuals require higher or lower doses to achieve an optimal therapeutic response, and tries to help the physician identify those pat...
متن کاملStrategies and Clinical Applications of Next Generation Sequencing
Abstract DNA sequencing is one of the great valuable techniques in molecular biology, which can be used to detect the sequence of nucleotides in a DNA fragment. The high-throughput sequencing known as Next Generation Sequencing (NGS) revolutionized genomic research and molecular biology; therefore, the whole human genome can be sequenced with a low cost in several days. NGS technology is simi...
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ژورنال
عنوان ژورنال: Genome Medicine
سال: 2011
ISSN: 1756-994X
DOI: 10.1186/gm294